DNA Curriculum Vitae
Helen Walter
 

 


 

 

 

 

 

 

 

Professional Experience

Visiting Assistant Professor (Aug 2005 - Present)

Introduction to Microbiology, Immunology, Genetics: Human Aspects

Mills College, Oakland, California, United States of America.

Adjunct Professor (Jun 2005 - Present)

Microbiology

Merritt College, Oakland, California, United States of America.

Adjunct Professor (Jan 2005 - Present)

Fundamentals of Microbiology, Fundamentals of Biological Science

Diablo Valley College, Pleasant Hill, California, United States of America.

Scientist (Feb 2002 - Aug 2004)

Protein Kinase C-epilson's role in the suppression of the Hypothalamus-Pituitary-Adrenal axis.

Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, United States of America.

Postdoctoral Research Fellow (May 1998 - Oct 2001)

The Role of Protein Kinase C-delta on L-type Calcium Channels in Alcohol Addiction.

Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, United States of America.

Research Assistant (Apr 1992 - Aug 1995)

The Role of Insulin-like Growth Factors in Central Nervous System Injuries.

Departments of Clinical Chemistry and Medicine, The Univeristy of Birmingham, United Kingdom.

Research Associate (Dec 1990 - Mar .1992)

The Role of Fibroblast Growth Factors in Angiogenesis.

Department of Physiology, The University of Birmingham, United Kingdom.

BSc. Sandwich Year Student (Sept 1988 - Sept 1989)

Construction of a Plasmid Containing the Serum Amyloid A Gene in a Form Suitable for Protein Structure/Function Studies.

Department of Molecular Rheumatology, Medical Research Council Centre for Clinical Research, London, United Kingdom.

 

Qualifications

Ph.D. in Molecular Neuroendocrinology (1992-1996)

The Spatio-Temporal Modulation of the Insulin-like Growth Factor Axis in the Central Nervous System: Implications for Endocrine, Paracrine and Autocrine Activities.

Molecular Neurosciences Group, Department of Medicine, Faculty of Medicine and Dentistry, The University of Birmingham, United Kingdom.


Publications

Hodge, C.W., Raber, J., McMahon, T., Walter, H., Sanchez-Perez, A.M., Olive, M.F., Mehmert, K., Morrow, A.L. and Messing, R.O. (2002) Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C epsilon. Journal of Clinical Investigation 110:1003-10

Walter, H.J., McMahon, T., Dadgar, J., Wang, D. and Messing, R.O. (2000) Ethanol Regulates Calcium Channel Subunits by Protein Kinase C delta-Dependent and Independent Mechanisms. The Journal of Biological Chemistry. 275:25717-25722

Walter, H.J. and Messing, R.O. (1999) Regulation of Neuronal Voltage-Gated Calcium Channels by Ethanol. Neurochem. Int. 35:95-101

Walter, H.J., Berry, M., Hill, D.J., Cwyfan-Hughes, S., Holly, J.M.P. and Logan, A. (1999) Distinct sites of Insulin-like growth factor (IGF)-II expression and localisation in lesioned rat brain: Possible roles of IGF binding proteins in the mediation of IGF-II activity. Endocrinology. 140: 520-532

Egginton, S., Hudlicka, O. Brown, M.D., Walter, H., Weiss, J.B., and Bate, A. (1998) Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle. J. App. Phy. 85: 2025-2032

Brown, M.D., Walter, H., Hansen-Smith, F.M., Hudlicka, O. and Egginton, S. (1998) Lack of Involvement of Basic Fibroblast Growth Factor (FGF-2) in Capillary Growth in Skeletal Muscles Exposed to Long-term Contractile Activity. Angiogenesis, 2:81-91

Walter, H.J., Berry, M., Hill, D.J. and Logan, A. (1997) Spatial and temporal changes in the insulin-like growth factor (IGF) axis indicate autocrine actions of IGF-I within wounds of the rat brain. Endocrinology, 138: 3024-3034

Walter, H.J., Berry, M., Hill, D.J., Cwyfan-Hughes, S., Holly, J.M.P. and Logan, A. (1996) Distinct sites of Insulin-like growth factor (IGF)-II expression and localisation in lesioned rat brain: Possible roles of IGF binding proteins in mediating IGF-II activity. J. Endocrinology, 164 (suppl): P63.

Patel, H., Bramall, J., Walter, H.J., DeBeer, M.C. and Woo, P. (1996) Expression of recombinant human serum amyloid-A in mammalian cells and demonstration of the region necessary for high-density lipoprotein binding and amyloid fibril formation by site-directed mutagenesis. Biochemical Journal, 318: 1041-1049.

Hudlicka, O., Brown, M.D., Walter, H., Weiss, J.B. and Bate A. (1995) Factors involve capillary growth in the heart. Molecular and Cellular Biochemistry, 147: 57-68

Walter, H.J., Berry, M. and Logan, A. (1995) Expression of IGF-I, IGF-II and IGFBP-2 in adult lesioned central nervous system (CNS). J. Endocrinology, 144 (suppl): P61.

Walter, H.J., Berry, M. Logan, A. (1994) The spatial and temporal response of insulin-like growth factors (IGF), IGF binding proteins (BP) and IGF receptors (R) in traumatic CNS injuries. J. Endocrinology, 140 (suppl): P66.

Walter, H.J., Hill, D. and Logan, A. (1994) Insulin-like growth factors (IGFs), IGFBPs and IGF receptors in the injured adult rat brain. Growth Regulation, 4: 104.

Brown, M.D., Walter, H.J., Weiss, J. and Hudlicka, O. (1993) Growth factors in angiogenesis in skeletal muscle and heart. FASEB J, 7: A880.

Walter, H. and Hudlicka, O. (1992) Expression of basic fibroblast growth factor in chronically stimulated skeletal muscles. Int. J. Microcirculation (clinical and experimental), 11.

Brown, M.D., Egginton, S., Walter, H.J. and Hudlicka, O. (1992) Increased capillary supply and localisation of basic fibroblast growth factor in rat fast skeletal muscle after stretch induced injury. Int. J. Microcirculation (clinical and experimental), 11.


Presentations

Walter, H.J., McMahon, T., Dadgar, J., Wang, D. Choi, D.-S. and Messing, R.O. (2000) Chronic Ethanol Exposure Mediates Increases In Specific Calcium Channel Subunits Via Protein Kinase C. Presented at The Society for Neuroscience, 30th Annual Meeting, New Orleans. 135.19

Walter, H.J., McMahon, T., Wang, D., Dadgar, J., Gerstin, E. Jr. and Messing, R.O. (1999) Protein Kinase C Delta-Mediated Increases in Calcium Channel Subunits Induced by Chronic Ethanol Exposure. Presented at 'Ethanol and Cell Signaling', a meeting organized by the American Society for Biochemistry and Molecular Biology, Lake Tahoe, CA, USA.

Walter, H.J., McMahon, T., Wang, D., Gerstin, E. Jr. and Messing, R.O. (1999) Changes in Calcium Channel Subunit Expression after Exposure to Chronic Ethanol. Presented at the Research Society for Alcoholism Annual Meeting, Santa Barbara, CA, USA.

Walter, H.J., Berry, M., Hill, D.J., Cwyfan-Hughes, S., Holly, J.M.P. and Logan, A. (1996) Distinct sites of Insulin-like growth factor (IGF)-II expression and localisation in lesioned rat brain: Possible roles of IGF binding proteins in mediating IGF-II activity. J. Endocrinology, 164 (suppl): P63. Presented at the 187th meeting of the Society of Endocrinology, London, UK. Nominated for a Sandoz award.

Walter, H.J., Berry, M. and Logan, A. (1995) Expression of IGF-I, IGF-II and IGFBP-2 in adult lesioned central nervous system (CNS). J. Endocrinology, 144 (suppl): P61. Presented at the 14th Joint meeting of the British Endocrine Societies, Warwick, UK.

Walter, H.J., Berry, M. Logan, A. (1994) The spatial and temporal response of insulin-like growth factors (IGF), IGF binding proteins (BP) and IGF receptors (R) in traumatic CNS injuries. J. Endocrinology, 140 (suppl): P66. Presented at the 185th meeting of the Society of Endocrinology, London, UK.

Walter, H.J., Hill, D. and Logan, A. (1994) Insulin-like growth factors (IGFs), IGFBPs and IGF receptors in the injured adult rat brain. Growth Regulation, 4: 104. Presented at the 3rd International symposium on Insulin-like growth factors, Sydney, Australia.

Walter, H. and Hudlicka, O. (1992) Expression of basic fibroblast growth factor in chronically stimulated skeletal muscles. Int. J. Microcirculation (clinical and experimental), 11 . Presented at the 12th International meeting of Microcirculation, Birmingham, UK.


Professional Activities

I possess a broad working knowledge of many techniques which include : RNA/DNA extraction, in situ hybridisation, immunocytochemistry, ribonuclease protection assay, PCR, Northern, Western, Southern and Dot blotting, Sequencing, In vitro mutagenesis, Restriction mapping, Subcloning, cell culture of various cell lines, transfection, electroporation, CAT/protein assays.

My experience also includes the supervision of BSc. project students and BSc. Intercalated students, that is those Medical students who opted to take a year out and study pathological science. My duties here extended to both instruction in the laboratory techniques they would be using and in the construction of their theses.

In addition to this I was a major participant on a series of courses that the laboratory ran for individuals from other universities and companies. This involved a number of lectures and contribution to a course book. Laboratory work was also included,in which I supervised course attendees.

I am able to utilise a number of word processing, statistical and drawing packages on both PC's and Macintosh. I also have experience with most aspects of the internet and accessing various databases. This also includes involvement with multi-user networks.

 

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© 1997- 2005 H. Walter
Last updated Marh 2005